Predex™ helps against multiple symptoms With its unique once a day formulation, Predex™ (diosmin) can help effectively against multiple symptoms. Supplements containing Predex™ are most often used by people with three common conditions: chronic venous insufficiency (CVI), a category that includes varicose veins, Heavy leg and swelling ; premenstrual syndrome (PMS) ; hemorrhoids and hemorrhoid crisis. We'll talk more about the basics of these common complaints and the important role that diosmin may play, in the sections below. These pages will allow you to learn how Predex™ can help you depending on your symptoms.       Chronic venous insufficiency  Varicose veins   Heavy Leg Syndrome (As a result of poor circulation, long distance traveling, and long term inactivity)   Severe edema or swelling of the leg, ankle and foot   Premenstrual syndrome (PMS)   Vascular and Premenstrual mastodynia   Hemorrhoids and hemorrhoid crisis   Capillary Fragility