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How Predex™ can help you? Chronic venous insufficiency
How Predex™ can help you ? Varicose vein  
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Chronic venous insufficiency
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Chronic venous insufficiency
 

Chronic venous insufficiency ? You're Not Alone !

Chronic Venous Insufficiency (CVI) is a medical catch-all term that refers to a variety of circulatory problems, usually involving the legs.

These circulatory problems start when blood begins to pool in the veins, stretching delicate vein tissue and producing tell-tale symptoms that may include spider veins, varicose veins, and localized swelling (or in medical-ese: "edema"). As time goes by, progressive damage to tiny one-way valves inside the veins produces the cluster of painful and distressing symptoms known as Chronic venous insufficiency.

 
 
INFOBOX | Chronic venous insufficiency Signs & Symptoms:

Edema (swelling) in the area of the foot or ankle is often the first noticeable symptom of Chronic venous insufficiency (CVI). [Boccalon; Clement].   see the "Swelling, edema" section

Over time, the constellation of symptoms experienced by Chronic venous insufficiency sufferers may include :

Difficulty walking
Pain while standing
Heavy leg / leg fatigue   see the "Heavy Leg" section
Burning, aching, or tightness in the calves
Night cramps or "charley horses"
Restless legs, especially at night
Varicose veins   see the "Varicose Vein" section
Itching, flaking skin
Discolored or leathery skin on ankles and legs
In severe cases, ulcers on lower leg or ankle (often slow to heal).

 
 


Thanks in part to our sedentary lifestyle, greater longevity, diet, and other factors, vein problems today afflict large segments of the world's adult population. Chronic Venous Insufficiency (CVI) involving the lower limbs is estimated to affect from 10-50% of men and 50-55% of women, while varicose veins make their unwanted appearance in as many as 33% of adult women and 20% of men. [Italian College of Phlebology]. Some studies suggest that varicose veins are one of the top three medical conditions, trailing only allergies and high blood pressure in overall prevalence. [Vannoni]

The vast majority of Chronic Venous Insufficiency (CVI) sufferers are women (by approximately 10 to 1). Vein problems also tend to appear at an earlier age in women than in men. [Boccalon]. By the age of 50, about 41% of women have developed some type of abnormal leg vein symptom.
While unsightly varicose veins can represent a significant source of frustration and distress for both men and women, Chronic Venous Insufficiency (CVI) is far more than just an "appearance" issue. Chronic Venous Insufficiency (CVI) takes a significant toll on such basic activities as climbing stairs, performing household chores, and the ability to simply stand for extended periods of time.

As Chronic Venous Insufficiency (CVI) progresses, leg ulcers may result in as many as 1% of the population, a potentially serious complication which tends to increase with age. [Simka]. Studies examining "quality of life" issues have observed that over 80% of leg ulcer sufferers report that the condition adversely affects their mobility, and can produce emotional feelings of anger, resentment, depression, and social isolation in addition to moderate to severe physical pain [Phillips]. And as if that weren't bad enough, the financial costs associated with Chronic Venous Insufficiency (CVI) have been estimated at more than $1 billion annually in the United States alone, according to one 2003 study. [Simka].

 
 
INFOBOX | DIAGNOSING Chronic Venous Insufficiency (CVI) : What To Expect When You See Your Doctor

Chronic Venous Insufficiency, like other medical conditions, requires a physician's training and expertise for an accurate diagnosis. Other medical problems can produce many of the same symptoms, including pain and swelling.

In addition to taking a complete medical history and performing a physical exam, your doctor may also order one or more tests to confirm a diagnosis of Chronic Venous Insufficiency :

Duplex ultrasound ("Doppler"), a test which uses high-frequency sound waves to assess the competence of valves, measure blood flow inside the veins, and rule out the presence of a blood clot.
Plethysmography, a very simple test in which multiple blood pressure cuffs are applied to compare systolic blood pressure in the arm with that in the leg. (Your blood pressure will normally read somewhat lower when measured at the leg than when taken on the arm, but this variation should be less than 20 mmHg.)
Venography, an imaging technique in which a contrast dye is injected into a vein, followed by an x-ray of the affected area to obtain a "picture" of the veins and to help identify possible clots

DON'T WAIT! SEEK IMMEDIATE MEDICAL HELP for:
A varicose vein that is RED in color (rather than the more usual blue);
A serious cut or injury to a varicose vein;
Severe pain and swelling in any extremity.

 
 


What Causes Chronic Venous Insufficiency ?


The short if not exactly sweet answer is that Chronic Venous Insufficiency results from damage to the one-way valves located inside the veins. This damage can stem from a variety of sources, including blood clots; trauma (injury) to the vein; high venous pressure; or simple progressive weaking of the vein wall from age. But to get a better understanding of Chronic Venous Insufficiency, it's important to look at the overall role that veins play in the body.

Our hearts push nutrient- and oxygen-rich blood out to the tissues through an array of branching arteries. Veins collect and feed blood back to the heart for re-oxygenation. But this return trip is anything but simple. For one thing, blood from our extremities has an uphill fight against gravity to reach the heart. And while the rhythmic influx of fresh blood provides a certain indirect push for the depleted blood, we don't have heart muscle beating at the tip of our toes to force blood back along its long return journey.
What we do have in our legs, however, are muscles located along the deep leg veins which actually contract to help "pump" blood back to the heart. This process works most effectively when the large leg muscles are active, as, for example, when you're walking. Long periods of sitting or standing tend to produce increased pressure inside the deep leg veins, as the blood moves back to the heart more sluggishly.

Working in parallel with the deep leg veins is another, more superficial, network of veins, located closer to the skin and carrying blood at far lower pressures. Connecting these two vein systems are "perforator" channels. If a faulty valve or blood clot increases pressure inside the deep veins, the perforator channels in turn "bleed off" excess pressure into the spidery superficial veins. These normally very small, elastic veins can in turn stretch and balloon, and additional one-way valves can be damaged.

One-way valves, as we've seen, are crucial to the success of the veins' pumping action. When these valves are not effective in preventing a backflow of blood, the result is Chronic Venous Insufficiency : chronic venous insufficiency.

Age alone increases the risk of Chronic Venous Insufficiency to some extent, since some loss of muscle tone and blood vessel elasticity typically accompanies the aging process. Other Chronic Venous Insufficiency risk factors include heredity; obesity; pregnancy; and smoking. Since long periods of sitting or standing can tend to promote blood pooling and reduce effective blood flow, Chronic Venous Insufficiencyalso tends to be job-related. Tight-fitting clothing such as girdles or boots can also contribute. Even as seemingly unrelated a conditon as constipation -- also a more prevalent condition for women and linked at least in part to inactivity -- may be a co-occurring condition or may, as a result of increased pressured from straining, directly contribute to Chronic Venous Insufficiency.

 
 
ILLUSTRATION | Leaky valve/reflux

Coming soon

 
 



 
 
INFOBOX | Can Vein Problems Be Prevented?

Chronic Venous Insufficiency tends to be a vicious cycle : blood pooling at weakened vein sites increases the pressure on delicate vein walls, which in turn produces further stretching of the veins and eventually damages delicate valves. These damaged valves then operate less efficiently, leading to further pooling, stretching, and damage.

Early intervention may help slow this insidious progression -- reducing both future symptoms and the high costs associated with CVI. The Boccalon study concluded: "In order to avoid progression to more severe forms which are disabling or expensive to treat, a rational approach to the management of early Chronic Venous Insufficiency is essential."

 
 
Diosmin and Veins :


Diosmin appears to increase the resistance and tonicity of capillaries, and to improve lymphatic drainage. The result : less swelling and less leg pain, with results noticeable in approximately one to two weeks.

A variety of scientific studies shed light on how diosmin may function in the body. Here's a brief look at what they say :

A 2002 study involving 5,052 Chronic venous insufficiency patients reported "continuous clinical improvement . . . throughout the study," with clinical scores for Chronic Venous Insufficiency-related pain, swelling, leg heaviness and cramps all showing significant decrease after treatment with micronized diosmin and hesperidin for 6 months. [Jantet].

The addition of micronized purified flavonoid fraction to compression and other conventional therapies for Chronic Venous Insufficiency patients with venous leg ulcers significantly increased the healing rate and reduces the healing time for ulcers, compared with conventional therapy alone [Simka; Smith].

Diosmin also significantly reduced reported discomfort of "heavy leg" syndrome. [Carpentier].

Flavonoids have similarly been shown to strengthen venous tone and improve the elasticity of veins in humans [Struckmann]; and to reduce platelet aggregation (clotting) and fibrinogen binding in rats [McGregor].

Flavonoids produced a 200% increase in lymphatic flow, along with decreased capillary permeability and increased capillary resistance, in a study involving dogs. [Struckmann]. Flavonoids' observed clinical efficacy on edema is believed to be due to improving lymphatic function and reduction of certain adhesion molecules, counteracting Chronic venous insufficiency-induced damage to microcirculation. [Ramelet]. Flavonoids may also help the body repair small blood vessel damage that leads to fluid permeability. [Chrystie 2001].

A protective effect against micro-circulatory damage from venular occlusion (closure) in rats was noted by researcher Takase; in a study on hamsters, Bouskela similarly noted improved micro-vascular reactivity (blood flow after artificially-induced blockage), and theorized that micronized flavonoid fraction "could function as an antioxidant, which may explain its beneficial therapeutic effect in chronic venous insufficiency where oxidative stress is involved in the pathological mechanism." Tantalizing clues about the possible mechanism of action explaining these results are offered in the following clinical studies:

Inflammation appears to be linked to both the development and the progression of Chronic Venous Insufficiency. In rat studies, diosmin was shown to have a protective effect against certain inflammation-causing substances. [Melin]. Hesperidin has also been shown to have significant anti-inflammatory and analgesic effects. [Galati; Emim]. One recent scientific paper reviewed the chemical mechanism by which flavonoids appear to inhibit certain regulatory enzymes, reducing inflammation. [Manthey].

Vein walls are regulated by adreno-receptors in the smooth muscle cells. Activation of these receptors by norepinephrine causes muscle contraction through a "calcium flux." [Vanhoutte]. Diosmin has been found to increase sensitivity to calcium (Ca2+), improving the smooth muscle contractile response. [Savineau].

Similarly, a small study conducted in Portugal reports that orally-administered diosmin appears to reduce the metabolism (using up) of muscle-activating noradrenalin. [Araujo].

The venoconstrictor effects of flavonoids may be explained in part by local inhibition of an enzyme known as COMT, and enhancement of sympathetic activity. Since norepinephrine is broken down by COMT, inhibition of this enzyme tends to increase vein tone. [Boudet].

 
 


INFOBOX | "Pro-Circulation" Supplements To Consider :

Supplements thought to promote circulation include :

Vitamin C
Vitamin E
Cayenne
Ginger

Some experts also recommend onions and garlic, which inhibit platelet aggregation (clotting) and may help to break up a protein called fibrin surrounding varicose veins.

For patients with leg ulcers, Vitamin A and Zinc may be useful to help promote healing.

Horse chestnut, though shown to promote circulation and decrease permeability of veins, can interact with certain medications and should be avoided by patients with liver or kidney problems.

 



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