Effect on Inflammatory Processes Predex™ has an anti-inflammatory activity related to an inhibition of prostaglandin synthesis. Diosmin opposes microcirculatory deterioration by inhibiting the expression of certain mediators involved in leukocyte or endothelial adhesion. Consequently, diosmin reduces both the activation and the adhesion of leukocytes as well as their migration through the microcapillary endothelium. This results in a decrease in pericapillary inflammation via inhibition of the release of the principal mediators of inflammation, principally free radical and prostaglandins. Therefore capillary permeability is normalized and capillary resistance is strengthened. Diosmin has also antioxydant activity.